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  1. Ulinastatin (UTI), recognized for its anti-inflammatory properties, holds promise for patients undergoing cardiac surgery. This study aimed to investigate the relationship between intraoperative UTI administra...

    Authors: Xiao Ran, Tingting Xu, Jieqiong Liu, Shaobing Yang, Fang Luo, Rongxue Wu, Juan Tan, Hang Ruan and Qin Zhang
    Citation: Critical Care 2025 29:52
    Content type: Research Published on:

  4. In severely injured trauma patients, hypofibrinoginaemia is associated with increased mortality. There is no evidence-based consensus for what constitutes optimal fibrinogen therapy, treatment dose or timing o...

    Authors: Tom Burt, Ashley Guilliam, Elaine Cole and Ross Davenport
    Citation: Critical Care 2025 29:49
    Content type: Research Published on:

  5. As compared to withholding parenteral nutrition (PN) until one week after intensive care unit (ICU) admission, Early PN prolonged ICU dependency in the EPaNIC randomized controlled trial (RCT). The Refeeding R...

    Authors: C. Lauwers, L. Langouche, P. J. Wouters, A. Wilmer, G. Van den Berghe, M. P. Casaer and J. Gunst
    Citation: Critical Care 2025 29:48
    Content type: Research Published on:

  6. Advanced respiratory monitoring through the measurement of esophageal pressure (Pes) as a surrogate of pleural pressure helps guiding mechanical ventilation in ICU patients. Pes measurement with an esophageal ...

    Authors: Julien P. van Oosten, Nico Goedendorp, Amne Mousa, Rutger C. Flink, Rik Schaart, Merel Flinsenberg, Peter Somhorst, Diederik A. M. P. J. Gommers, Leo Heunks and Annemijn H. Jonkman
    Citation: Critical Care 2025 29:47
    Content type: Research Published on:

  11. Conflicting data exist regarding sex-specific outcomes after cardiac arrest. This study investigates sex disparities in the provision of critical care and outcomes of in-hospital (IHCA) and out-of-hospital car...

    Authors: Simon A. Amacher, Tobias Zimmermann, Pimrapat Gebert, Pascale Grzonka, Sebastian Berger, Martin Lohri, Valentina Tröster, Ketina Arslani, Hamid Merdji, Catherine Gebhard, Sabina Hunziker, Raoul Sutter, Martin Siegemund and Caroline E. Gebhard
    Citation: Critical Care 2025 29:42
    Content type: Research Published on:

  12. In-hospital cardiac arrest (IHCA) poses a considerable threat to hospitalized patients, leading to high mortality rates and severe neurological deficits among survivors. Despite the advancements in resuscitati...

    Authors: Feng-Cheng Chang, Ming-Jer Hsieh, Jih-Kai Yeh, Victor Chien-Chia Wu, Yu-Ting Cheng, An-Hsun Chou, Chia-Pin Lin, Chip‐Jin Ng, Shao-Wei Chen and Chun-Yu Chen
    Citation: Critical Care 2025 29:41
    Content type: Research Published on:

  14. Critical care nurses are vulnerable to depression, which not only lead to poor well-being and increased turnover intention, but also affect their working performances and organizational productivity as well. W...

    Authors: Xuting Li, Yusheng Tian, Jiaxin Yang, Meng Ning, Zengyu Chen, Qiang Yu, Yiting Liu, Chongmei Huang and Yamin Li
    Citation: Critical Care 2025 29:39
    Content type: Research Published on:

    The Matters Arising to this article has been published in Critical Care 2025 29:61

  15. Rapid, adequate treatment is crucial to reduce mortality in sepsis. Risk stratification scores used at emergency departments (ED) are limited in detecting all septic patients with increased mortality risk. We ...

    Authors: Maria Andersson, Karin Fröderberg Schooner, Viktor Karlsson Werther, Thomas Karlsson, Lina De Geer, Daniel B. Wilhelms, Martin Holmbom, Mats Fredrikson, Åse Östholm, Sören Berg and Håkan Hanberger
    Citation: Critical Care 2025 29:38
    Content type: Research Published on:

  16. Microcirculatory alterations are predictive of poor outcomes in patients with shock and after cardiac arrest in animal models. However, microcirculatory alterations during human cardiac arrest have not yet bee...

    Authors: Matthias Mueller, Michael Holzer, Heidrun Losert, Daniel Grassmann, Florian Ettl, Mathias Gatterbauer, Ingrid Magnet, Alexander Nuernberger, Calvin Lukas Kienbacher, Georg Gelbenegger, Michael Girsa, Harald Herkner and Mario Krammel
    Citation: Critical Care 2025 29:37
    Content type: Research Published on:

  17. Aneurysmatic subarachnoid hemorrhage (aSAH) is a critical condition associated with significant mortality rates and complex rehabilitation challenges. Early prediction of functional outcomes is essential for o...

    Authors: Masamichi Moriya, Kenji Karako, Shogo Miyazaki, Shin Minakata, Shuhei Satoh, Yoko Abe, Shota Suzuki, Shohei Miyazato and Hikaru Takara
    Citation: Critical Care 2025 29:36
    Content type: Research Published on:

  19. Intermediate care units (IMCUs) provide care for patients who need more intensive treatment than general wards but less than intensive care units (ICUs). Although the concept of an IMCU requires co-location wi...

    Authors: Hiroyuki Ohbe, Daisuke Kudo, Yuya Kimura, Hiroki Matsui, Hideo Yasunaga and Shigeki Kushimoto
    Citation: Critical Care 2025 29:34
    Content type: Research Published on:

  20. Phospholipid transfer protein (PLTP), a glycoprotein widely expressed in the body, is primarily involved in plasma lipoprotein metabolism. Previous research has demonstrated that PLTP can exert anti-inflammato...

    Authors: Wei Jiang, Lin Song, Weilei Gong, Xianghui Li, Keran Shi, Luanluan Li, Chuanqing Zhang, Jing Wang, Xiaolan Xu, Haixia Wang, Xiaoyan Wu, Jun Shao, Yang Yu, Jiangquan Yu and Ruiqiang Zheng
    Citation: Critical Care 2025 29:33
    Content type: Research Published on:

    The Matters Arising to this article has been published in Critical Care 2025 29:127

    The Matters Arising to this article has been published in Critical Care 2025 29:83

  21. Carbapenem-Resistant Gram-Negative Bacteria, including Carbapenem-Resistant Enterobacterales (CRE) and Carbapenem-Resistant Pseudomonas aeruginosa (CRPA), are common causes of infections in intensive care units (...

    Authors: Gennaro De Pascale, Andrea Cortegiani, Matteo Rinaldi, Massimo Antonelli, Sergio Cattaneo, Maurizio Cecconi, Raffaele Cuffaro, Lidia Dalfino, Filomena Di Biase, Abele Donati, Francesca Romana Fasano, Teresa Fasciana, Giuseppe Foti, Antonella Frattari, Roberto Fumagalli, Massimo Girardis…
    Citation: Critical Care 2025 29:32
    Content type: Research Published on:

  22. Authors: Youn‑Jung Kim, Yong Hwan Kim, Chun Song Youn, In Soo Cho, Su Jin Kim, Jung Hee Wee, Yoo Seok Park, Joo Suk Oh, Byung Kook Lee and Won Young Kim
    Citation: Critical Care 2025 29:31
    Content type: Correction Published on:

    The original article was published in Critical Care 2023 27:313

  23. Low-volume hypertonic solutions, such as half-molar lactate (LAC), may be a potential treatment used for fluid resuscitation. This study aimed to evaluate the underlying cardiovascular effects and mechanisms o...

    Authors: Kristoffer Berg-Hansen, Nigopan Gopalasingam, Mette Glavind Bülow Pedersen, Jakob Tobias Nyvad, Nikolaj Rittig, Esben Søndergaard, Henrik Wiggers, Niels Møller and Roni Nielsen
    Citation: Critical Care 2025 29:30
    Content type: Research Published on:

    The Matters Arising to this article has been published in Critical Care 2025 29:166

  24. Despite intensive clinical and scientific efforts, the mortality rate of sepsis remains high due to the lack of precise biomarkers for patient stratification and therapeutic guidance. Interleukin 40 (IL-40), a...

    Authors: Shijie Cai, Xiao Li, Chen Zhang, Yuqian Jiang, Yonghui Liu, Zhi He, Shuo Ma, Yuming Yao, Chun-Kwok Wong, Guoqiu Wu and Xun Gao
    Citation: Critical Care 2025 29:29
    Content type: Research Published on:

  25. In patients with acute hypoxemic respiratory failure (AHRF) under mechanical ventilation, the change in pressure slope during a low-flow insufflation indicates a global airway opening pressure (AOP) needed to ...

    Authors: Nannan Sun, Clement Brault, Antenor Rodrigues, Matthew Ko, Fernando Vieira, Vorakamol Phoophiboon, Michel Slama, Lu Chen and Laurent Brochard
    Citation: Critical Care 2025 29:28
    Content type: Research Published on:

  26. Despite the physiological advantages of positive end-expiratory pressure (PEEP), its optimal utilization during one-lung ventilation (OLV) remains uncertain. We aimed to investigate whether individualized PEEP...

    Authors: Wan-Jie Gu, Feng-Zhi Zhao, Federico Piccioni, Rui Shi, Xiang Si, Shuo Chen, Maurizio Cecconi and Hai-Yan Yin
    Citation: Critical Care 2025 29:27
    Content type: Research Published on:

  27. Traumatic brain injury (TBI) is a major public health concern worldwide, contributing to high rates of injury-related death and disability. Severe traumatic brain injury (sTBI), although it accounts for only 1...

    Authors: Mohammad M. Banoei, James Hutchison, William Panenka, Andy Wong, David S. Wishart and Brent W. Winston
    Citation: Critical Care 2025 29:26
    Content type: Research Published on:

  29. Antibody-negative autoimmune encephalitis (AE) is a form of encephalitis characterized by the absence of detectable autoimmune antibodies, despite immunological evidence. However, data on management of patient...

    Authors: Zhiyi Li, Xiaofeng He, Dongrui Li, Ruixia Yuan, Yifei Zhai, Junfang Teng and Wenjing Deng
    Citation: Critical Care 2025 29:24
    Content type: Research Published on:

  30. Both quantitative and qualitative aspects of muscle status significantly impact clinical outcomes in critically ill patients. Comprehensive monitoring of baseline muscle status and its changes is crucial for r...

    Authors: Natsuhiro Yamamoto, Kentaro Tojo, Takahiro Mihara, Rae Maeda, Yuki Sugiura and Takahisa Goto
    Citation: Critical Care 2025 29:23
    Content type: Research Published on:

  31. Conflicts between ICU staff and patient/relatives are common and are a source of additional stress in an already tense environment. These conflicts vary from disagreements to serious controversies, which may l...

    Authors: Victoria Metaxa, Flavio E. Nacul and Anna Conway Morris
    Citation: Critical Care 2025 29:22
    Content type: Perspective Published on:

    The Matters Arising to this article has been published in Critical Care 2025 29:145

    The Matters Arising to this article has been published in Critical Care 2025 29:53

  32. Patients admitted to the intensive care unit (ICU) often have gut colonization with pathogenic bacteria and such colonization is associated with increased risk for death and infection. We conducted a trial to ...

    Authors: Heekuk Park, Elissa Lynch, Alice Tillman, Kristen Lewis, Zhezhen Jin, Anne-Catrin Uhlemann, Julian A. Abrams and Daniel E. Freedberg
    Citation: Critical Care 2025 29:21
    Content type: Brief Report Published on:

  33. The oxygen reactivity index (ORx) reflects the correlation between focal brain tissue oxygen (pbtO2) and the cerebral perfusion pressure (CPP). Previous, small cohort studies were conflicting on whether ORx conve...

    Authors: Teodor Svedung Wettervik, Erta Beqiri, Anders Hånell, Stefan Yu Bögli, Ihsane Olakorede, Xuhang Chen, Adel Helmy, Andrea Lavinio, Peter J. Hutchinson and Peter Smielewski
    Citation: Critical Care 2025 29:20
    Content type: Research Published on:

  34. Double cycling with breath-stacking (DC/BS) during controlled mechanical ventilation is considered potentially injurious, reflecting a high respiratory drive. During partial ventilatory support, its occurrence...

    Authors: Roberto Brito, Caio C. A. Morais, Daniel H. Arellano, Abraham I. J. Gajardo, Alejandro Bruhn, Laurent J. Brochard, Marcelo B. P. Amato and Rodrigo A. Cornejo
    Citation: Critical Care 2025 29:19
    Content type: Brief Report Published on:

  35. Pulse pressure variation (PPV) is limited in low tidal volume mechanical ventilation. We conducted this systematic review and meta-analysis to evaluate whether passive leg raising (PLR)-induced changes in PPV ...

    Authors: Jihad Mallat, Matthew T. Siuba, Osama Abou-Arab, Pedja Kovacevic, Khaled Ismail, Abhijit Duggal and Pierre-Grégoire Guinot
    Citation: Critical Care 2025 29:18
    Content type: Review Published on:

  36. Patients supported by extracorporeal membrane oxygenation (ECMO) are at a high risk of brain injury, contributing to significant morbidity and mortality. This study aimed to employ machine learning (ML) techni...

    Authors: Bixin Deng, Zhe Zhao, Tiechao Ruan, Ruixi Zhou, Chang’e Liu, Qiuping Li, Wenzhe Cheng, Jie Wang, Feng Wang, Haixiu Xie, Chenglong Li, Zhongtao Du, Wenting Lu, Xiaohong Li, Junjie Ying, Tao Xiong…
    Citation: Critical Care 2025 29:17
    Content type: Research Published on:

  38. Continuous electroencephalography (cEEG) has been recommended in critically ill patients although its efficacy for improving patients’ functional status remains unclear. This study aimed to compare the efficac...

    Authors: Chusak Limotai, Suda Jirasakuldej, Sattawut Wongwiangiunt, Tipakorn Tumnark, Piradee Suwanpakdee, Kwuanrat Wangponpattanasiri, Piyanuch Rakchue, Chaiwiwat Tungkasereerak, Polchai Pleumpanupatand, Phopsuk Tansuhaj, Phattarawin Ekkachon, Songchai Kittipanprayoon, Apiwoot Kerddonfag, Thippamas Pobsuk, Anuchate Pattanateepapon, Kammant Phanthumchinda…
    Citation: Critical Care 2025 29:15
    Content type: Research Published on:

  42. Predicting complete liberation from mechanical ventilation (MV) is still challenging. Electrical impedance tomography (EIT) offers a non-invasive measure of regional ventilation distribution and could bring ad...

    Authors: Vorakamol Phoophiboon, Antenor Rodrigues, Fernando Vieira, Matthew Ko, Fabiana Madotto, Annia Schreiber, Nannan Sun, Mayson L. A. Sousa, Mattia Docci, Clement Brault, Luca S. Menga, Irene Telias, Thomas Piraino, Ewan C. Goligher and Laurent Brochard
    Citation: Critical Care 2025 29:11
    Content type: Research Published on:

  45. Nutrition interventions commenced in ICU and continued through to hospital discharge have not been definitively tested in critical care to date. To commence a program of research, we aimed to determine if a ta...

    Authors: Emma J. Ridley, Michael Bailey, Marianne J. Chapman, Lee-anne S. Chapple, Adam M. Deane, Marlene Gojanovic, Alisa M. Higgins, Carol L. Hodgson, Victoria L. King, Andrea P. Marshall, Eliza G. Miller, Shay P. McGuinness, Rachael L. Parke, Eldho Paul and Andrew A. Udy
    Citation: Critical Care 2025 29:8
    Content type: Research Published on:

  47. Targeted temperature management (TTM) is considered a beneficial treatment for improving outcomes in patients with OHCA due to acute coronary syndrome (ACS). The comparative benefits of hypothermic TTM (32–34°...

    Authors: Tasuku Matsuyama, Bon Ohta, Makoto Watanabe and Tetsuhisa Kitamura
    Citation: Critical Care 2025 29:6
    Content type: Research Published on:

  49. Limited data is available to evaluate the burden of device associated healthcare infections (HAI) [central line associated bloodstream infection (CLABSI), catheter associated urinary tract infection (CAUTI), a...

    Authors: Bruno Martins Tomazini, Bruno Adler Maccagnan Pinheiro Besen, Renato Hideo Nakagawa Santos, Antonio Paulo Nassar Jr., Thabata Silva Veiga, Viviane Bezerra Campos, Samira Martins Tokunaga, Elton Sousa Santos, Leticia Galvão Barbante, Renato da Costa Maia, Flavia Cristina Soares Kojima, Ligia Nasi Laranjeira, Leandro Utino Taniguchi, Roberta Muriel Longo Roepke, Cristiano Augusto Franke, Luciana Coelho Sanches…
    Citation: Critical Care 2025 29:4
    Content type: Research Published on:
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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535