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Articles

Page 5 of 384

  1. Despite intensive clinical and scientific efforts, the mortality rate of sepsis remains high due to the lack of precise biomarkers for patient stratification and therapeutic guidance. Interleukin 40 (IL-40), a...

    Authors: Shijie Cai, Xiao Li, Chen Zhang, Yuqian Jiang, Yonghui Liu, Zhi He, Shuo Ma, Yuming Yao, Chun-Kwok Wong, Guoqiu Wu and Xun Gao
    Citation: Critical Care 2025 29:29
    Content type: Research Published on:

  2. In patients with acute hypoxemic respiratory failure (AHRF) under mechanical ventilation, the change in pressure slope during a low-flow insufflation indicates a global airway opening pressure (AOP) needed to ...

    Authors: Nannan Sun, Clement Brault, Antenor Rodrigues, Matthew Ko, Fernando Vieira, Vorakamol Phoophiboon, Michel Slama, Lu Chen and Laurent Brochard
    Citation: Critical Care 2025 29:28
    Content type: Research Published on:

  3. Despite the physiological advantages of positive end-expiratory pressure (PEEP), its optimal utilization during one-lung ventilation (OLV) remains uncertain. We aimed to investigate whether individualized PEEP...

    Authors: Wan-Jie Gu, Feng-Zhi Zhao, Federico Piccioni, Rui Shi, Xiang Si, Shuo Chen, Maurizio Cecconi and Hai-Yan Yin
    Citation: Critical Care 2025 29:27
    Content type: Research Published on:

  4. Traumatic brain injury (TBI) is a major public health concern worldwide, contributing to high rates of injury-related death and disability. Severe traumatic brain injury (sTBI), although it accounts for only 1...

    Authors: Mohammad M. Banoei, James Hutchison, William Panenka, Andy Wong, David S. Wishart and Brent W. Winston
    Citation: Critical Care 2025 29:26
    Content type: Research Published on:

  6. Antibody-negative autoimmune encephalitis (AE) is a form of encephalitis characterized by the absence of detectable autoimmune antibodies, despite immunological evidence. However, data on management of patient...

    Authors: Zhiyi Li, Xiaofeng He, Dongrui Li, Ruixia Yuan, Yifei Zhai, Junfang Teng and Wenjing Deng
    Citation: Critical Care 2025 29:24
    Content type: Research Published on:

  7. Both quantitative and qualitative aspects of muscle status significantly impact clinical outcomes in critically ill patients. Comprehensive monitoring of baseline muscle status and its changes is crucial for r...

    Authors: Natsuhiro Yamamoto, Kentaro Tojo, Takahiro Mihara, Rae Maeda, Yuki Sugiura and Takahisa Goto
    Citation: Critical Care 2025 29:23
    Content type: Research Published on:

  8. Conflicts between ICU staff and patient/relatives are common and are a source of additional stress in an already tense environment. These conflicts vary from disagreements to serious controversies, which may l...

    Authors: Victoria Metaxa, Flavio E. Nacul and Anna Conway Morris
    Citation: Critical Care 2025 29:22
    Content type: Perspective Published on:

    The Matters Arising to this article has been published in Critical Care 2025 29:145

    The Matters Arising to this article has been published in Critical Care 2025 29:53

  9. Patients admitted to the intensive care unit (ICU) often have gut colonization with pathogenic bacteria and such colonization is associated with increased risk for death and infection. We conducted a trial to ...

    Authors: Heekuk Park, Elissa Lynch, Alice Tillman, Kristen Lewis, Zhezhen Jin, Anne-Catrin Uhlemann, Julian A. Abrams and Daniel E. Freedberg
    Citation: Critical Care 2025 29:21
    Content type: Brief Report Published on:

  10. The oxygen reactivity index (ORx) reflects the correlation between focal brain tissue oxygen (pbtO2) and the cerebral perfusion pressure (CPP). Previous, small cohort studies were conflicting on whether ORx conve...

    Authors: Teodor Svedung Wettervik, Erta Beqiri, Anders Hånell, Stefan Yu Bögli, Ihsane Olakorede, Xuhang Chen, Adel Helmy, Andrea Lavinio, Peter J. Hutchinson and Peter Smielewski
    Citation: Critical Care 2025 29:20
    Content type: Research Published on:

  11. Double cycling with breath-stacking (DC/BS) during controlled mechanical ventilation is considered potentially injurious, reflecting a high respiratory drive. During partial ventilatory support, its occurrence...

    Authors: Roberto Brito, Caio C. A. Morais, Daniel H. Arellano, Abraham I. J. Gajardo, Alejandro Bruhn, Laurent J. Brochard, Marcelo B. P. Amato and Rodrigo A. Cornejo
    Citation: Critical Care 2025 29:19
    Content type: Brief Report Published on:

  12. Pulse pressure variation (PPV) is limited in low tidal volume mechanical ventilation. We conducted this systematic review and meta-analysis to evaluate whether passive leg raising (PLR)-induced changes in PPV ...

    Authors: Jihad Mallat, Matthew T. Siuba, Osama Abou-Arab, Pedja Kovacevic, Khaled Ismail, Abhijit Duggal and Pierre-Grégoire Guinot
    Citation: Critical Care 2025 29:18
    Content type: Review Published on:

  13. Patients supported by extracorporeal membrane oxygenation (ECMO) are at a high risk of brain injury, contributing to significant morbidity and mortality. This study aimed to employ machine learning (ML) techni...

    Authors: Bixin Deng, Zhe Zhao, Tiechao Ruan, Ruixi Zhou, Chang’e Liu, Qiuping Li, Wenzhe Cheng, Jie Wang, Feng Wang, Haixiu Xie, Chenglong Li, Zhongtao Du, Wenting Lu, Xiaohong Li, Junjie Ying, Tao Xiong…
    Citation: Critical Care 2025 29:17
    Content type: Research Published on:

  15. Continuous electroencephalography (cEEG) has been recommended in critically ill patients although its efficacy for improving patients’ functional status remains unclear. This study aimed to compare the efficac...

    Authors: Chusak Limotai, Suda Jirasakuldej, Sattawut Wongwiangiunt, Tipakorn Tumnark, Piradee Suwanpakdee, Kwuanrat Wangponpattanasiri, Piyanuch Rakchue, Chaiwiwat Tungkasereerak, Polchai Pleumpanupatand, Phopsuk Tansuhaj, Phattarawin Ekkachon, Songchai Kittipanprayoon, Apiwoot Kerddonfag, Thippamas Pobsuk, Anuchate Pattanateepapon, Kammant Phanthumchinda…
    Citation: Critical Care 2025 29:15
    Content type: Research Published on:

  19. Predicting complete liberation from mechanical ventilation (MV) is still challenging. Electrical impedance tomography (EIT) offers a non-invasive measure of regional ventilation distribution and could bring ad...

    Authors: Vorakamol Phoophiboon, Antenor Rodrigues, Fernando Vieira, Matthew Ko, Fabiana Madotto, Annia Schreiber, Nannan Sun, Mayson L. A. Sousa, Mattia Docci, Clement Brault, Luca S. Menga, Irene Telias, Thomas Piraino, Ewan C. Goligher and Laurent Brochard
    Citation: Critical Care 2025 29:11
    Content type: Research Published on:

  22. Nutrition interventions commenced in ICU and continued through to hospital discharge have not been definitively tested in critical care to date. To commence a program of research, we aimed to determine if a ta...

    Authors: Emma J. Ridley, Michael Bailey, Marianne J. Chapman, Lee-anne S. Chapple, Adam M. Deane, Marlene Gojanovic, Alisa M. Higgins, Carol L. Hodgson, Victoria L. King, Andrea P. Marshall, Eliza G. Miller, Shay P. McGuinness, Rachael L. Parke, Eldho Paul and Andrew A. Udy
    Citation: Critical Care 2025 29:8
    Content type: Research Published on:

  24. Targeted temperature management (TTM) is considered a beneficial treatment for improving outcomes in patients with OHCA due to acute coronary syndrome (ACS). The comparative benefits of hypothermic TTM (32–34°...

    Authors: Tasuku Matsuyama, Bon Ohta, Makoto Watanabe and Tetsuhisa Kitamura
    Citation: Critical Care 2025 29:6
    Content type: Research Published on:

  26. Limited data is available to evaluate the burden of device associated healthcare infections (HAI) [central line associated bloodstream infection (CLABSI), catheter associated urinary tract infection (CAUTI), a...

    Authors: Bruno Martins Tomazini, Bruno Adler Maccagnan Pinheiro Besen, Renato Hideo Nakagawa Santos, Antonio Paulo Nassar Jr., Thabata Silva Veiga, Viviane Bezerra Campos, Samira Martins Tokunaga, Elton Sousa Santos, Leticia Galvão Barbante, Renato da Costa Maia, Flavia Cristina Soares Kojima, Ligia Nasi Laranjeira, Leandro Utino Taniguchi, Roberta Muriel Longo Roepke, Cristiano Augusto Franke, Luciana Coelho Sanches…
    Citation: Critical Care 2025 29:4
    Content type: Research Published on:

  28. External lumbar drainage (ELD) of cerebrospinal fluid may help control intracranial pressure following a traumatic brain injury. We aimed to assess the efficacy and safety of ELD in post-traumatic intracranial...

    Authors: Geoffrey Dagod, Marlène Laurens, Jean-Paul Roustan, Pauline Deras, Elie Courvalin, Mehdi Girard, Hugues Weber, Xavier Capdevila and Jonathan Charbit
    Citation: Critical Care 2025 29:2
    Content type: Research Published on:

  32. Rapid multiplex molecular syndromic panels (RMMSP) (3 or more pathogens and time-to-results < 6 h) allow simultaneous detection of multiple pathogens and genotypic resistance markers. Their implementation has ...

    Authors: Francisco Javier Candel, Miguel Salavert, Rafael Cantón, José Luis del Pozo, Fátima Galán-Sánchez, David Navarro, Alejandro Rodríguez, Juan Carlos Rodríguez, Montserrat Rodríguez-Aguirregabiria, Borja Suberviola and Rafael Zaragoza
    Citation: Critical Care 2024 28:440
    Content type: Review Published on:

  33. Excessive exposure to adrenergic vasopressors may be harmful. Non-adrenergic vasopressors may spare adrenergic agents and potentially improve outcomes. We aimed to conduct a systematic review and meta-analysis...

    Authors: Yuki Kotani, Alessandro Belletti, Filippo D’Amico, Alessandra Bonaccorso, Patrick M. Wieruszewski, Tomoko Fujii, Ashish K. Khanna, Giovanni Landoni and Rinaldo Bellomo
    Citation: Critical Care 2024 28:439
    Content type: Research Published on:

  36. Entropy quantifies the level of disorder within a system. Low entropy reflects increased rigidity of homeostatic feedback systems possibly reflecting failure of protective physiological mechanisms like cerebra...

    Authors: Stefan Yu Bögli, Ihsane Olakorede, Erta Beqiri, Xuhang Chen, Ari Ercole, Peter Hutchinson and Peter Smielewski
    Citation: Critical Care 2024 28:436
    Content type: Research Published on:

  37. Medical advances in intensive care units (ICUs) have resulted in the emergence of a new patient population—those who survive the initial acute phase of critical illness, but require prolonged ICU stays and dev...

    Authors: Hiroyuki Ohbe, Kasumi Satoh, Takaaki Totoki, Atsushi Tanikawa, Kasumi Shirasaki, Yoshihide Kuribayashi, Miku Tamura, Yudai Takatani, Hiroyasu Ishikura and Kensuke Nakamura
    Citation: Critical Care 2024 28:435
    Content type: Review Published on:

  38. Listening and responding to family concerns in organ and tissue donation is generally considered important, but has never been researched in real time. We aimed to explore in real time, (a) which family concer...

    Authors: Sanne P. C. van Oosterhout, Anneke G. van der Niet, Wilson F. Abdo, Marianne Boenink, Jelle L. P. van Gurp and Gert Olthuis
    Citation: Critical Care 2024 28:434
    Content type: Research Published on:

  39. Ultra-protective ventilation is the combination of low airway pressures and tidal volume (Vt) combined with extra corporeal carbon dioxide removal (ECCO2R). A recent large study showed no benefit of ultra-protect...

    Authors: Clément Monet, Thomas Renault, Yassir Aarab, Joris Pensier, Albert Prades, Ines Lakbar, Clément Le Bihan, Mathieu Capdevila, Audrey De Jong, Nicolas Molinari and Samir Jaber
    Citation: Critical Care 2024 28:433
    Content type: Research Published on:

    The Matters Arising to this article has been published in Critical Care 2025 29:156

    The Matters Arising to this article has been published in Critical Care 2025 29:121

  40. Sepsis is the result of a dysregulated immune response to infection and is associated with acute organ dysfunction. The syndrome’s complexity is contingent upon the underlying pathology and individual patient ...

    Authors: Gabriella Bottari, Vito Marco Ranieri, Can Ince, Antonio Pesenti, Filippo Aucella, Anna Maria Scandroglio, Claudio Ronco and Jean-Louis Vincent
    Citation: Critical Care 2024 28:432
    Content type: Review Published on:

    The Matters Arising to this article has been published in Critical Care 2025 29:123

    The Matters Arising to this article has been published in Critical Care 2025 29:45

  41. Lipids play a critical role in defense against sepsis. We sought to investigate gene expression and lipidomic patterns of lipid dysregulation in sepsis.

    Authors: Beulah Augustin, Dongyuan Wu, Lauren Page Black, Andrew Bertrand, Dawoud Sulaiman, Charlotte Hopson, Vinitha Jacob, Jordan A. Shavit, Daniel A. Hofmaenner, Guillaume Labilloy, Leslie Smith, Emilio Cagmat, Kiley Graim, Susmita Datta, Srinivasa T. Reddy and Faheem W. Guirgis
    Citation: Critical Care 2024 28:431
    Content type: Research Published on:

  43. In septic shock, the classic fluid resuscitation strategy can lead to a potentially harmful positive fluid balance. This multicenter, randomized, single-blind, parallel, controlled pilot study assessed the eff...

    Authors: Nicolas Boulet, Jean-Pierre Quenot, Chris Serrand, Nadiejda Antier, Sylvain Garnier, Aurèle Buzancais, Laurent Muller, Claire Roger, Jean-Yves Lefrant and Saber Davide Barbar
    Citation: Critical Care 2024 28:429
    Content type: Research Published on:

  44. Authors: Rong Li, JuanJuan Wang, Qian Li, QianYue Guo, Jun Kang Zhao, James Cheng-Chung Wei and Li-Yun Zhang
    Citation: Critical Care 2024 28:428
    Content type: Matters Arising Published on:

    The original article was published in Critical Care 2024 28:282

    The Matters Arising to this article has been published in Critical Care 2025 29:131

  45. Intracranial multimodal monitoring (iMMM) is increasingly used in neurocritical care, but a lack of standardization hinders its evidence-based development. Here, we devised core outcome sets (COS) and reportin...

    Authors: Sami Barrit, Mejdeddine Al Barajraji, Salim El Hadwe, Alexandre Niset, Brandon Foreman, Soojin Park, Christos Lazaridis, Lori Shutter, Brian Appavu, Matthew P. Kirschen, Felipe A. Montellano, Verena Rass, Nathan Torcida, Daniel Pinggera, Emily Gilmore, Nawfel Ben-Hamouda…
    Citation: Critical Care 2024 28:427
    Content type: Consensus Article Published on:

  46. Perioperative airway management and oxygenation maintenance during central airway obstruction (CAO) treatment pose great challenges. While veno-venous extracorporeal membrane oxygenation (V-V ECMO) shows promi...

    Authors: Xiao-xiu Luo, Jia-jia Li, Fu-xun Yang, Yu Lei, Fan Zeng, Yun-ping Lan, Chun Pan, Xiao-bo Huang, Rong-an Liu and Jing-chao Luo
    Citation: Critical Care 2024 28:426
    Content type: Brief Report Published on:

  47. Oliguria diagnosis includes the normalization of urine output (UO) by body weight. However, the rational and the method to apply to normalize UO to body weight are unclear. We aimed to explore the impact of th...

    Authors: Céline Monard, Nicolas Tebib, Bastien Trächsel, Tatiana Kelevina and Antoine Guillaume Schneider
    Citation: Critical Care 2024 28:425
    Content type: Research Published on:
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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535