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  1. Sepsis gene-expression sub-phenotypes with prognostic and theranostic potential have been discovered. These have been identified retrospectively and have not been translated to methods that could be deployed a...

    Authors: David B. Antcliffe, Estelle Peronnet, Frédéric Pène, Kristoffer Strålin, David Brealey, Sophie Blein, Richard Cleaver, Maria Cronhjort, Jean-Luc Diehl, Guillaume Voiriot, Aurore Fleurie, Claudia Lannsjö, Anne-Claire Lukaszewicz, Johan Mårtensson, Tài Pham, Nicolas De Prost…
    Citation: Critical Care 2025 29:98
    Content type: Research Published on:

  2. Diagnosing septic shock promptly is essential but challenging, especially due to its clinical similarity to non-septic shock. Extracellular vesicle-derived miRNAs may serve as biomarkers to distinguish septic ...

    Authors: Adrián García-Concejo, Belén Sánchez-Quirós, Esther Gómez-Sánchez, Laura Sánchez-de Prada, Álvaro Tamayo-Velasco, María Sherezade Tovar-Doncel, Mario Lorenzo, Estefanía Gómez-Pesquera, Rodrigo Poves-Álvarez, David Bernardo, Marta Martín-Fernández, Hugo Gonzalo-Benito, Paula Moreno-Portales, Rosa Prieto-Utrera, Miguel Bardají-Carrillo, Rocío López-Herrero…
    Citation: Critical Care 2025 29:96
    Content type: Research Published on:

  5. Fluid dynamics during and after a septic event is complex, but better knowledge could guide both fluid resuscitation and fluid removal. We aimed to compare fluid dynamics before and after sepsis in a clinicall...

    Authors: Son Ly Hong, Hugo Dumargne, Robert G. Hahn, Abdessalem Hammed, Romain Lac, Axel Guilpin, Charlotte Slek, Maxime Gerome, Bernard Allaouchiche, Vanessa Louzier and Auguste Dargent
    Citation: Critical Care 2025 29:92
    Content type: Research Published on:

  6. In critical illness, all elements of gut function are perturbed. Dysbiosis develops as the gut microbial community loses taxonomic diversity and new virulence factors appear. Intestinal permeability increases,...

    Authors: Danielle E. Soranno, Craig M. Coopersmith, Jessica F. Brinkworth, Faith N. F. Factora, Julia H. Muntean, Monty G. Mythen, Jacob Raphael, Andrew D. Shaw, Vidula Vachharajani and Jeannette S. Messer
    Citation: Critical Care 2025 29:91
    Content type: Consensus Article Published on:

  8. Authors: Alexandre Demoule, Amandine Baptiste, Arnaud W. Thille, Thomas Similowski, Stephanie Ragot, Gwénael Prat, Alain Mercat, Christophe Girault, Guillaume Carteaux, Thierry Boulain, Sébastien Perbet, Maxens Decavèle, Lisa Belin and Jean-Pierre Frat
    Citation: Critical Care 2025 29:89
    Content type: Correction Published on:

    The original article was published in Critical Care 2024 28:174

  9. Acute respiratory distress syndrome (ARDS) is a severe complication of critical illness, characterized by bilateral lung infiltrates and hypoxemia. Its clinical and pathophysiological heterogeneity poses chall...

    Authors: Lou’i Al-Husinat, Saif Azzam, Sarah Al Sharie, Mohammad Araydah, Denise Battaglini, Suhib Abushehab, Gustavo A. Cortes-Puentes, Marcus J. Schultz and Patricia R. M. Rocco
    Citation: Critical Care 2025 29:88
    Content type: Review Published on:

  11. In the Intensive Care Unit (ICU), clinicians frequently make complex, high-stakes judgments, where inaccuracies can profoundly affect patient outcomes. This perspective examines human judgment error in ICU set...

    Authors: I. P. Peringa, E. G. M. Cox, R. Wiersema, I. C. C. van der Horst, R. R. Meijer and J. Koeze
    Citation: Critical Care 2025 29:86
    Content type: Perspective Published on:

  13. Medication waste is a contributor to the healthcare environmental footprint and impacts ecosystems. Data on medication waste in the intensive care unit (ICU) are scarce, and therefore are essential to develop ...

    Authors: Erwan d’Aranda, Stéphanie Pons, Jonathan Chelly, Enora Atchade, Laure Bonnet, Claire Dahyot-Fizelier, Toufik Kamel, Fanny Giannoni, Olivier Collange, Emmanuel Besnier, Mathieu Schoeffler, Nicolas Mayeur, Pierre-Louis Quere, Ludivine Marecal, Cyril Pernod, Cyrille Geay…
    Citation: Critical Care 2025 29:84
    Content type: Research Published on:

  15. The ratio of pulse-oximetric peripheral oxygen saturation to fraction of inspired oxygen (SpO2/FiO2) has been proposed as additional hypoxemia criterion in a new global definition of acute respiratory distress sy...

    Authors: Rolf Erlebach, Una Pale, Tilman Beck, Sasa Markovic, Marko Seric, Sascha David and Emanuela Keller
    Citation: Critical Care 2025 29:82
    Content type: Research Published on:

  16. No standardized index exists to assess cardiovascular responsiveness to angiotensin-II. We hypothesized that a standardized index of initial blood pressure response to angiotensin-II treatment would be associa...

    Authors: Daniel E. Leisman, Patrick M. Wieruszewski, Laurence W. Busse, Lakhmir S. Chawla, Kathryn A. Hibbert, Damian R. Handisides, Ashish K. Khanna, Marlies Ostermann, Michael T. McCurdy, Christopher D. Adams, Tony N. Hodges and Rinaldo Bellomo
    Citation: Critical Care 2025 29:81
    Content type: Research Published on:

  17. Mitigating environmental impacts is an urgent challenge supported by (scientific) intensive care societies worldwide. However, making green choices without compromising high-quality care for critically ill pat...

    Authors: Elisabeth Smale, Heather Baid, Marko Balan, Forbes McGain, Scott McAlistar, Jan J. de Waele, Jan Carel Diehl, Erik van Raaij, Michel van Genderen, Dick Tibboel and Nicole Hunfeld
    Citation: Critical Care 2025 29:80
    Content type: Perspective Published on:

  18. Infections are a leading cause of early mortality after liver transplantation (LT). Prior to transplantation, cirrhosis-associated immune dysfunction significantly increases the risk of infection. This study i...

    Authors: M. C. Delignette, A. Riff, T. Antonini, T. Soustre, M. Bodinier, E. Peronnet, F. Venet, M. Gossez, S. Pantel, J. Y. Mabrut, X. Muller, K. Mohkam, F. Villeret, D. Erard, J. Dumortier, F. Zoulim…
    Citation: Critical Care 2025 29:79
    Content type: Research Published on:

  19. Morphological analysis of intracranial pressure (ICP) pulse waveforms provides indirect information on cerebrospinal compliance, which might be reduced by space-occupying lesions but also by intracranial hyper...

    Authors: Magdalena Kasprowicz, Cyprian Mataczyński, Agnieszka Uryga, Adam I. Pelah, Eric Schmidt, Marek Czosnyka and Agnieszka Kazimierska
    Citation: Critical Care 2025 29:78
    Content type: Research Published on:

  21. Serum cardiac troponin (cTn) elevation is a well-established phenomenon in sepsis. However, the clinical significance of this phenomenon with high-sensitivity (hs) assays and the current sepsis definition need...

    Authors: Abraham I. J. Gajardo, Santiago Ferrière-Steinert, Joaquín Valenzuela Jiménez, Sebastián Heskia Araya, Thomas Kouyoumdjian Carvajal, José Ramos-Rojas and Juan Nicolás Medel
    Citation: Critical Care 2025 29:76
    Content type: Research Published on:

    The Matters Arising to this article has been published in Critical Care 2025 29:118

  22. Authors: Annalisa Boscolo, Andrea Bruni, Marco Giani, Eugenio Garofalo, Nicolò Sella, Tommaso Pettenuzzo, Michela Bombino, Matteo Palcani, Emanuele Rezoagli, Matteo Pozzi, Elena Falcioni, Elisa Pistollato, Eugenio Biamonte, Francesco Murgolo, Graziella D’Arrigo, Mercedes Gori…
    Citation: Critical Care 2025 29:75
    Content type: Correction Published on:

    The original article was published in Critical Care 2024 28:279

  24. The p-value has changed from a versatile tool for scientific reasoning to a strict judge of medical information, with the usual 0.05 cutoff frequently deciding a study’s significance and subsequent clinical use. ...

    Authors: Sharad Patel and Adam Green
    Citation: Critical Care 2025 29:73
    Content type: Perspective Published on:

    The Matters Arising to this article has been published in Critical Care 2025 29:135

  25. Large language models (LLMs) show increasing potential for their use in healthcare for administrative support and clinical decision making. However, reports on their performance in critical care medicine is la...

    Authors: Jessica D. Workum, Bas W. S. Volkers, Davy van de Sande, Sumesh Arora, Marco Goeijenbier, Diederik Gommers and Michel E. van Genderen
    Citation: Critical Care 2025 29:72
    Content type: Research Published on:

  26. Despite widespread vaccination programs, pertussis continues circulating within populations and remains a life-threatening infection in infants. While several mortality risk factors have been described, a comp...

    Authors: Vladimir L. Cousin, Caroline Caula, Jason Vignot, Raphael Joye, Matthieu Blanc, Clémence Marais and Pierre Tissières
    Citation: Critical Care 2025 29:71
    Content type: Research Published on:

  29. Airway mucus is a highly specialised secretory fluid which functions as a physical and immunological barrier to pathogens whilst lubricating the airways and humifying atmospheric air. Dysfunction is common dur...

    Authors: Thomas Roe, Thomas Talbot, Isis Terrington, Jayant Johal, Ivan Kemp, Kordo Saeed, Elizabeth Webb, Rebecca Cusack, Michael P. W. Grocott and Ahilanandan Dushianthan
    Citation: Critical Care 2025 29:68
    Content type: Review Published on:

  30. The optimal hemoglobin (Hb) threshold to trigger red blood cell transfusions (RBCT) in subarachnoid hemorrhage (SAH) patients is unclear. This study evaluated the impact of liberal versus restrictive transfusi...

    Authors: Chahnez Taleb, Elisa Gouvea Bogossian, Carla Bittencour Rynkowski, Kirsten Møller, Piet Lormans, Manuel Quintana Diaz, Anselmo Caricato, Luigi Zattera, Pedro Kurtz, Geert Meyfroidt, Herve Quintard, Maria Celeste Dias, Angelo Giacomucci, Charlotte Castelain, Russell Chabanne, Pilar Marcos-Neira…
    Citation: Critical Care 2025 29:67
    Content type: Research Published on:

  31. Postoperative sepsis is a severe complication associated with increased mortality and potential long-term cognitive decline, including dementia. However, the relationship between postoperative sepsis and demen...

    Authors: Mingyang Sun, Fangfang Li, Yangyang Wang, Mengrong Miao, Zhongyuan Lu, Wan-Ming Chen, Szu-Yuan Wu and Jiaqiang Zhang
    Citation: Critical Care 2025 29:66
    Content type: Research Published on:

  32. Although potent P2Y12 inhibitors, such as ticagrelor and prasugrel, are standard treatment in patients with acute myocardial infarction (AMI), evidence for their efficacy and safety compared with clopidogrel is l...

    Authors: Jinhwan Jo, Seung Hun Lee, Hyun Sung Joh, Hyun Kuk Kim, Ju Han Kim, Young Joon Hong, Young Keun Ahn, Myung Ho Jeong, Seung Ho Hur, Doo-Il Kim, Kiyuk Chang, Hun Sik Park, Jang-Whan Bae, Jin-Ok Jeong, Yong Hwan Park, Kyeong Ho Yun…
    Citation: Critical Care 2025 29:65
    Content type: Research Published on:

  33. Assessing and quantifying recruitability are important for characterizing ARDS severity and for reducing or preventing the atelectrauma caused by the cyclic opening and closing of pulmonary units. Over the yea...

    Authors: Stefano Giovanazzi, Domenico Nocera, Giulia Catozzi, Francesca Collino, Massimo Cressoni, Lorenzo Ball, Onnen Moerer, Michael Quintel, Luigi Camporota and Luciano Gattinoni
    Citation: Critical Care 2025 29:64
    Content type: Review Published on:

  34. Time to positivity (TTP) and differential TTP (DTP) emerge as diagnostic and prognostic tools for bloodstream infections (BSI) though specific cut-off values need to be determined for each pathogen. Pseudomonas a...

    Authors: Daniel N. Marco, Maria Brey, Sergi Anguera, Cristina Pitart, Ignacio Grafia, Marta Bodro, Jose Antonio Martínez, Ana del Río, Carolina Garcia-Vidal, Abiu Sempere, Celia Cardozo, Pedro Puerta-Alcalde, Mariana Chumbita, Marta Hernández-Meneses, Guillermo Cuervo, Patricia Monzo-Gallo…
    Citation: Critical Care 2025 29:63
    Content type: Research Published on:

    The Matters Arising to this article has been published in Critical Care 2025 29:143

    The Matters Arising to this article has been published in Critical Care 2025 29:94

  35. Relatives of intensive care unit (ICU) patients often endure symptoms of post-traumatic stress, anxiety, and depression during and after treatment of a family member’s hospitalization. The aim of this study wa...

    Authors: Denzel L. Q. Drop, Johan H. Vlake, Evert-Jan Wils, Jasper Van Bommel, Christian Jung, Denise E. Hilling, O. Joseph Bienvenu, Tim I. M. Korevaar, Anna F. C. Schut, Margo M. C. van Mol, Diederik Gommers and Michel E. van Genderen
    Citation: Critical Care 2025 29:62
    Content type: Research Published on:

  37. Passive leg raising (PLR) is a well-recognized method for assessing volume responsiveness in the intensive care unit (ICU); however, it has some limitations. The physiology of the cardiac preload induced by th...

    Authors: Zhiyong Wang, Jie Zhang, Jing Zhao, Yaxuan Wu, Shiya Zhang, Chengfen Yin, Xinjing Gao and Lei Xu
    Citation: Critical Care 2025 29:60
    Content type: Research Published on:

  38. Neutrophils release neutrophil extracellular traps (NETs) as part of a healthy host immune response. NETs physically trap and kill pathogens as well as activating and facilitating crosstalk between immune cell...

    Authors: Andrew Retter, Mervyn Singer and Djillali Annane
    Citation: Critical Care 2025 29:59
    Content type: Review Published on:

  39. The application of sepsis subtypes to enhance personalized medicine in critically ill patients is hindered by the lack of validation across diverse cohorts and the absence of a simple classification model. We ...

    Authors: Rombout B. E. van Amstel, Emma Rademaker, Jason N. Kennedy, Lieuwe D. J. Bos, Hessel Peters-Sengers, Joe M. Butler, Niklas Bruse, Dave A. Dongelmans, Matthijs Kox, Alexander P. J. Vlaar, Tom van der Poll, Olaf L. Cremer, Christopher W. Seymour and Lonneke A. van Vught
    Citation: Critical Care 2025 29:58
    Content type: Research Published on:

  40. Capillary refill time (CRT) and skin blood flow (SBF) have been reported to be strong predictors of mortality in critically ill patients. However, the relationship between both parameters remains unclear.

    Authors: Alexandra Morin, Louai Missri, Tomas Urbina, Vincent Bonny, Maxime Gasperment, Juliette Bernier, Jean-Luc Baudel, Eduardo Kattan, Eric Maury, Jérémie Joffre and Hafid Ait-Oufella
    Citation: Critical Care 2025 29:57
    Content type: Research Published on:

  42. Pathogen identification is essential in sepsis and septic shock. Metagenomic next-generation sequencing (mNGS) is a novel pathogen detection method with several advantages over traditional tests. However, the ...

    Authors: Chengxi Liu, Xiao Song, Jihai Liu, Liang Zong, Tao Xu, Xu Han, Fan Li, Bo Li, Huadong Zhu and Di Shi
    Citation: Critical Care 2025 29:55
    Content type: Review Published on:

  43. To use natural language processing (NLP) to study the incidence, characteristics, trajectory, associations, and outcomes of hallucinations and disturbed behaviour in intensive care unit (ICU) patients.

    Authors: Thomas Niccol, Marcus Young, Natasha E. Holmes, Kartik Kishore, Sobia Amjad, Michele Gaca, Rinaldo Bellomo and Ary Serpa Neto
    Citation: Critical Care 2025 29:54
    Content type: Research Published on:

  45. Ulinastatin (UTI), recognized for its anti-inflammatory properties, holds promise for patients undergoing cardiac surgery. This study aimed to investigate the relationship between intraoperative UTI administra...

    Authors: Xiao Ran, Tingting Xu, Jieqiong Liu, Shaobing Yang, Fang Luo, Rongxue Wu, Juan Tan, Hang Ruan and Qin Zhang
    Citation: Critical Care 2025 29:52
    Content type: Research Published on:

  48. In severely injured trauma patients, hypofibrinoginaemia is associated with increased mortality. There is no evidence-based consensus for what constitutes optimal fibrinogen therapy, treatment dose or timing o...

    Authors: Tom Burt, Ashley Guilliam, Elaine Cole and Ross Davenport
    Citation: Critical Care 2025 29:49
    Content type: Research Published on:

  49. As compared to withholding parenteral nutrition (PN) until one week after intensive care unit (ICU) admission, Early PN prolonged ICU dependency in the EPaNIC randomized controlled trial (RCT). The Refeeding R...

    Authors: C. Lauwers, L. Langouche, P. J. Wouters, A. Wilmer, G. Van den Berghe, M. P. Casaer and J. Gunst
    Citation: Critical Care 2025 29:48
    Content type: Research Published on:
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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535