Table 1 Patient characteristics by cirrhosis diagnosis
From: Identifying a unique signature of sepsis in patients with pre-existing cirrhosis
No cirrhosis (n = 2591) | Cirrhosis (n = 371) | p-value | |
|---|---|---|---|
Demographics | |||
Male sex | 1412 (55%) | 240 (65%) | <0.001 |
Race | <0.001 | ||
White | 1460 (56%) | 245 (66%) | |
Black | 916 (35%) | 94 (25%) | |
Asian and Pacific Islander | 104 (4%) | 15 (4%) | |
Native American | 6 (< 1%) | 0 (0%) | |
Other/unknown | 105 (4%) | 17 (5%) | |
Hispanic ethnicity | 72 (3%) | 21 (6%) | |
Age, years | 63 (52, 72) | 59 (52, 66) | <0.001 |
Body mass index (kg/m2) | 26 (22, 30) | 27 (23, 30) | 0.31 |
Medical history | |||
Cancer | 574 (22%) | 371 (12%) | <0.001 |
Chronic kidney disease | 461 (18%) | 81 (22%) | 0.070 |
End-stage renal disease | 178 (7%) | 33 (9%) | 0.19 |
Hypertension | 1466 (57%) | 182 (49%) | 0.02 |
Diabetes mellitus | 797 (31%) | 125 (34%) | 0.46 |
HIV | 24 (1%) | 2 (1%) | 0.71 |
Congestive heart failure | 433 (17%) | 48 (13%) | 0.08 |
Severity | |||
APACHE-III | 86 (64, 114) | 99 (78, 128) | <0.001 |
SOFA score | 8 (4, 12) | 12 (8, 15) | <0.001 |
Admission source | |||
Source | <0.001 | ||
ED | 1315 (51%) | 130 (35%) | |
Other hospital ward | 1009 (39%) | 184 (50%) | |
Outside hospital | 267 (10%) | 57 (15%) | |
Substance use history | |||
History of alcohol use | <0.001 | ||
Never | 1557 (61%) | 156 (39%) | |
Former | 668 (26%) | 38 (10%) | |
Current | 233 (9%) | 177 (48%) | |
Unknown | 133 (5%) | 10 (3%) | |
History of smoking | <0.001 | ||
Never | 1235 (48%) | 139 (38%) | |
Former | 999 (39%) | 158 (43%) | |
Current | 246 (10%) | 59 (16%) | |
Unknown | 111 (4%) | 15 (4%) | |
Sepsis source | |||
Source | <0.001 | ||
Genitourinary | 237 (9%) | 30 (8%) | |
Abdominal/GI | 373 (14%) | 119 (32%) | |
Pulmonary | 1426 (55%) | 145 (39%) | |
Head/neck | 26 (1%) | 1 (< 1%) | |
Blood | 250 (10%) | 31 (8%) | |
Skin/soft-tissue/bone | 84 (3%) | 13 (4%) | |
Gynecologic | 2 (< 1%) | 0 (0%) | |
Unknown | 193 (7%) | 32 (9%) | |
Therapeutics day 0 | |||
Systemic steroids | 938 (36%) | 103 (28%) | 0.002 |
Vasopressors | 1271 (49%) | 220 (59%) | 0.001 |