Table 3 Secondary outcomes
Outcomes | Early administration group (n = 40) | Late administration group (n = 42) | P value |
|---|---|---|---|
Change of vasopressor-inotrope score from 0 to 48 h of ICU admission, median (IQR) | − 31.0 (− 41.9–− 23.8) | − 23.4 (− 32.4–− 10.7) | 0.0047 |
Change of sequential organ failure assessment score from day 1 to day 3 of ICU admission, median (IQR) | 0 (− 2–3) | 2 (− 1–3) | 0.39 |
Total amount of fluid within 48 h of ICU admission, ml, median (IQR) | 8404 (6527–10,946) | 7357 (6098–10565) | 0.70 |
ICU-free days during 28 days, days, median (IQR) | 18 (1–23) | 14 (0–19) | 0.025 |
Ventilator-free days during 28 days, days, median (IQR) | 22 (6–25) | 19 (0–23) | 0.081 |
Vasopressor/inotrope-free days during 28 days, days, median (IQR) | 23 (21–25) | 21 (0–24) | 0.027 |
Kidney replacement therapy-free days during 28 days, days, median (IQR) | 25 (22–28) | 25 (0–28) | 0.39 |
28 day mortality, n (%) | 4 (10) | 10 (24) | 0.097 |
ICU mortality, n (%) | 4 (10) | 9 (21) | 0.16 |
In-hospital mortality, n (%) | 6 (15) | 13 (31) | 0.087 |