Table 1 Baseline characteristics of intention-to-treat population
Characteristic | Vitamin C (N = 147) | Control (N = 145) |
|---|---|---|
Age [yr]—mean (SD) | 64.7 (16.2) | 67.0 (13.9) |
Female sex—N (%) | 50 (34.0) | 53 (36.6) |
Weight [kg]—mean (SD) | 78.2 (21.2) | 78.9 (17.2) |
NEWS score at admission—median (Q1, Q3) | 8.0 (7.0; 10.0) | 8.0 (6.0; 10.0) |
Sepsis etiology—N (%) | ||
Respiratory | 68 (46.3) | 77 (53.1) |
Gastro-intestinal | 11 (7.5) | 12 (8.3) |
Urinary | 28 (19.1) | 34 (23.5) |
Skin or soft tissue | 17 (11.6) | 10 (6.9) |
Catheter | 2 (1.4) | 1 (0.7) |
Other | 21 (14.3) | 11 (7.6) |
SOFA score—median (Q1, Q3) | 4.0 (2.0; 7.0) | 4.0 (3.0; 7.0) |
SOFA score > = 6 N (%) | 51 (34.7) | 53 (36.6) |
Septic shock—N (%) | 18 (12.2) | 23 (15.9) |
MAP < 65 mmHg N (%) | 57 (38.8) | 46 (31.7) |
CRP [mg/dL]—mean (SD) | 191.9 (138.2) | 192.2 (144.1) |
Procalcitonin [ng/mL]—median (Q1, Q3) | 3.2 (0.6; 13.5) | 4.0 (0.8; 22.4) |
Lactate [mmol/L]—mean (SD) | 2.7 (2.6) | 2.8 (2.1) |
Treatment—N (%) | ||
Corticosteroids | 39 (26.5) | 30 (20.7) |
Mechanical ventilation needed | 24 (16.3) | 22 (15.2) |
Vasoactive agents | 41 (27.9) | 37 (25.5) |
RRT | 3 (2.0) | 3 (2.1) |
Fluid balance D1 [mL]—mean (SD) | 1680 (1710) | 1695 (1625) |
EQ Index—mean (SD) | 0.452 (0.453) | 0.421 (0.448) |