Table 1 Factors associated with shorter TTP. Univariate and multivariate analysis.
Characteristics | TTP < 15 h (N = 600) | TTP > 15 h (N = 577) | p-value | Multivariate analysis | |
|---|---|---|---|---|---|
OR | p-value | ||||
Age > 64 years | 297 (49.5) | 314 (54.4) | 0.1 | ||
Sex (female) | 233 (38.8) | 164 (28.4) | < 0.001 | ||
Comorbidities | |||||
Foreign body | 239 (39.8) | 268 (46.4) | 0.025 | ||
Diabetes mellitus | 116 (19.3) | 129 (22.4) | 0.22 | ||
Chronic pneumopathy | 63 (10.5) | 68 (11.8) | 0.52 | ||
CKD | 96 (16) | 75 (13) | 0.16 | ||
CKD hemodialysis | 41 (6.8) | 21 (3.6) | 0.02 | ||
Chronic liver disease | 40 (6.7) | 34 (5.9) | 0.63 | ||
Solid neoplasm | 147 (24.5) | 148 (25.6) | 0.7 | ||
Hematologic malignancy | 127 (21.2) | 107 (18.5) | 0.27 | ||
Neutropenia | 131 (21.8) | 84 (14.9) | 0.013 | ||
Solid organ transplantation | 78 (13) | 97 (16.8) | 0.07 | ||
Stem cell transplantation | 38 (6.3) | 30 (5.2) | 0.45 | ||
HIV | 21 (3.5) | 19 (3.3) | 0.9 | ||
Corticosteroids | 224 (37.3) | 169 (29.3) | < 0.001 | ||
Admission data | |||||
Previous admission (< 1 month) | 183 (31.5) | 199 (35.5) | 0.15 | ||
Nosocomial bacteremia | 550 (53.5) | 478 (46.5) | < 0.001 | ||
Bladder catheterization | 193 (33) | 225 (40.1) | 0.02 | ||
Intravascular catheter | 489 (81.5) | 370 (64.1) | < 0.001 | 2.4 [1.5–3.7] | < 0.001 |
Microbiologic data | |||||
PAE isolated in aerobic 2/2 vials | 352 (58.8) | 236 (40.1) | < 0.001 | 1.5 [1.2–1.8] | < 0.001 |
Sensible to ceftazidime | 458 (81.6) | 377 (72.4) | < 0.001 | ||
Sensible to piperacillin | 402 (81.4) | 337 (69.2) | < 0.001 | ||
Sensible to gentamycin | 381 (81.2) | 330 (73.3) | 0.005 | ||
Sensible to amikacin | 548 (97.3) | 526 (96.9) | 0.7 | ||
Sensible to ciprofloxacin | 411 (72.4) | 348 (64.9) | 0.01 | ||
Sensible to meropenem | 355 (73.8) | 297 (63.2) | < 0.001 | ||
Susceptible PAE | 377 (63.9) | 317 (56.7) | 0.01 | ||
MDR PAE | 55 (9.2) | 88 (15.3) | 0.002 | 0.4 [0.2–0.7] | < 0.001 |
Active antibiotic (during bacteremia) | 66 (11) | 90 (15.6) | 0.02 | 0.35 [0.2–0.5] | < 0.001 |
Source of infection | |||||
Primary bacteremia | 127 (21.5) | 127 (22.3) | 0.8 | ||
Catheter-related | 281 (47.5) | 112 (19.6) | < 0.001 | 2.9 [2.1–4] | < 0.001 |
Respiratory | 77 (12.8) | 84 (14.6) | 0.4 | ||
Abdominal | 14 (2.4) | 33 (5.8) | 0.004 | ||
Biliary tract | 19 (3.2) | 42 (7.4) | 0.002 | ||
Urinary tract | 49 (8.3) | 130 (22.8) | < 0.001 | 0.5 [0.3–0.8] | 0.008 |