Association between mean hemodynamic variables during the first 24 h and outcomes in cardiogenic shock: identification of clinically relevant thresholds

Levy, Bruno; Curtiaud, Anais; Duarte, Kevin; Delmas, Clément; Demiselle, Julien; Girerd, Nicolas; Gebhard, Caroline Eva; Helms, Julie; Meziani, Ferhat; Kimmoun, Antoine; Merdji, Hamid

doi:10.1186/s13054-025-05356-0

Critical Care

Table 3 Association of macrocirculatory hemodynamic and tissue perfusion variables with endpoints in univariable Cox model

From: Association between mean hemodynamic variables during the first 24 h and outcomes in cardiogenic shock: identification of clinically relevant thresholds

	N_events/N (%)	Univariable cox model		Prognostic value
	N_events/N (%)	HR (CI 95%)	p value	C-index (CI 95%)	p value
Outcome = death at 30 days
Mean SAP (per 10 mmHg decrease)	44/118 (37%)	1.41 (1.14–1.74)	0.001	0.635 (0.552–0.718)	0.001
Mean SAP < 95 mmHg	44/118 (37%)	2.09 (1.10–3.94)	0.024	0.580 (0.510–0.650)	0.025
Mean MAP (per 10 mmHg decrease)	44/118 (37%)	1.74 (1.25–2.41)	0.0010	0.644 (0.560–0.728)	0.0008
Mean MAP < 70 mmHg	44/118 (37%)	1.89 (1.04–3.43)	0.037	0.584 (0.510–0.657)	0.027
Mean ScvO₂ (per 1% decrease)	43/115 (37%)	1.03 (1.00–1.06)	0.023	0.600 (0.506–0.693)	0.036
Mean ScvO₂ < 70%	43/115 (37%)	1.80 (0.99–3.28)	0.054	0.586 (0.511–0.661)	0.025
Mean CO (per 1 L/min decrease)	43/114 (38%)	1.62 (1.24–2.13)	0.0004	0.668 (0.581–0.756)	0.0002
Mean CO < 3.5 L/min	43/114 (38%)	2.38 (1.30–4.33)	0.005	0.617 (0.544–0.691)	0.002
Mean CI (per 1 L/min/m² decrease)	44/117 (38%)	2.04 (1.24–3.34)	0.005	0.626 (0.538–0.715)	0.005
Mean CI ≤ 1.8 L/min/m²	44/117 (38%)	1.81 (0.96–3.41)	0.068	0.577 (0.503–0.651)	0.042
Mean CPI (per 0.1 W/m² decrease)	44/117 (38%)	1.57 (1.19–2.08)	0.001	0.648 (0.563–0.732)	0.0006
Mean CPI < 0.27 W/m²	44/117 (38%)	2.37 (1.22–4.61)	0.011	0.584 (0.516–0.653)	0.016
Mean ∆PCO₂ (per 1 mmHg increase)	43/114 (38%)	1.14 (1.07–1.22)	0.0001	0.623 (0.529–0.717)	0.010
Mean ∆PCO₂ ≥ 9 mmHg	43/114 (38%)	2.75 (1.51–5.02)	0.0010	0.629 (0.556–0.702)	0.0005
Mean ∆PCO₂/C(a-v)O₂ (per 1 mmHg/mL increase)	42/113 (37%)	1.10 (1.02–1.18)	0.012	0.610 (0.527–0.694)	0.009
Mean ∆PCO₂/C(a-v)O₂ ≥ 1.5 mmHg/mL	42/113 (37%)	2.15 (1.08–4.29)	0.029	0.598 (0.532–0.665)	0.004
Mean arterial lactate (per 1 mmol/L increase)	42/116 (36%)	1.29 (1.20–1.38)	< 0.0001	0.764 (0.685–0.842)	< 0.0001
Mean arterial lactate ≥ 3 mmol/L	42/116 (36%)	4.18 (2.13–8.19)	< 0.0001	0.687 (0.623–0.751)	< 0.0001

SAP: systolic arterial pressure; MAP: mean arterial pressure; CO: cardiac output; CI: cardiac index; CPI: cardiac power index; ScvO₂: central venous oxygen saturation; P(v-a)CO₂/C(a-v)O₂ ratio: ratio of venous-arterial carbon dioxide tension difference to arterial-venous oxygen content difference (or ∆PCO₂/C(a-v)O₂)
CI: confidence interval, HR: hazard ratio

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ISSN: 1364-8535

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