Table 2 Association between mechanical left ventricular unloading with survival time up to 90 days in patients receiving extracorporeal membrane resuscitation
Result | Hazards ratio (95%-CI) |
|---|---|
Propensity score-matched cohort | 0.92 (0.79–1.08) |
Sensitivity analyses | |
Inverse probability treatment weighting | 0.92 (0.82–1.03) |
Complete case analysis (propensity score matched) | 0.99 (0.86–1.15) |
Including sex in the propensity score-matching algorithm | 0.92 (0.80–1.06) |
Double adjustment on propensity score-matching algorithm | 0.94 (0.81–1.09) |
Target trial emulations | |
ARREST trial | 1.17 (0.84–1.63) |
Prague OHCA trial | 0.92 (0.77–1.10) |
INCEPTION trial | 1.05 (0.79–1.40) |
Subgroup analyses | |
Type of mechanical unloading device (p-interaction = 0.87) | |
IABP | 0.91 (0.74–1.12) |
mLVAD | 0.89 (0.68–1.16) |
Aetiology of cardiac arrest (p = interaction = 0.97) | |
Cardiac | 0.92 (0.78–1.10) |
Non-cardiac | 0.91 (0.43–1.93) |
Presenting rhythm (p-interaction = 0.067) | |
Shockable | 1.06 (0.84–1.33) |
Nonshockable | 0.79 (0.64–0.98) |
Location of arrest (p-interaction = 0.88) | |
Out-of-hospital cardiac arrest | 0.91 (0.69–1.19) |
In-hospital cardiac arrest | 0.88 (0.73–1.06) |
Interaction analyses | |
Centre volume (per 10 cases per year) | 1.03 (0.97–1.10) |
Age (per 10 years) | 0.99 (0.88–1.12) |
Duration of CPR prior to ECMO (per 10 min) | 0.95 (0.90–1.01) |