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Fig. 2 | Critical Care

Fig. 2

From: Pyroptosis in sepsis-associated acute kidney injury: mechanisms and therapeutic perspectives

Fig. 2

Two-step activation process of the NLRP3 inflammasome.In Step 1 (initiation), pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), derived from viruses and bacteria, activate pattern recognition receptors, leading to the activation of NF-κB and upregulation of NLRP3 expression. In Step 2 (activation), NLRP3 agonists trigger the assembly of the NLRP3 inflammasome complex, which includes NLRP3, ASC, and caspase-1. This activation results in the formation of the functional inflammasome, initiating downstream inflammatory responses

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Critical Care

ISSN: 1364-8535