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Table 4 Biomarkers

From: Cardiovascular effects of lactate in healthy adults

 

LAC

SAL

Difference (95% CI)

P value

Baseline

After treatment

Baseline

After treatment

pH

7.35 ± 0.01

7.43 ± 0.06

7.38 ± 0.02

7.35 ± 0.02

0.12 (0.09, 0.14)

 < 0.001

HCO3 mmol/L

25.0 ± 1.1

29.6 ± 7.0

25.2 ± 1.3

23.5 ± 1.1

6.7 (3.7, 9.7)

 < 0.001

pCO2, kPa

6.8 ± 0.5

6.5 ± 0.4

6.2 ± 0.4

6.1 ± 0.4

− 0.2 (− 0.4, 0.1)

0.190

Hematcrite

44.0 ± 3.2

40.3 ± 2.2

43.7 ± 2.4

39.9 ± 2.1

0.7 (0.0, 1.3)

0.053

Sodium, mmol/L

142 ± 1

146 ± 1

141 ± 2

146 ± 1

− 1 (− 2, − 1)

 < 0.001

Chloride, mmol/L

108 ± 2

107 ± 4

108 ± 1

117 ± 3

− 10 (− 11, − 9)

 < 0.001

Calcium, mmol/L

1.21 ± 0.02

1.15 ± 0.03

1.22 ± 0.03

1.18 ± 0.02

− 0.03 (− 0.04, − 0.02)

 < 0.001

Potassium, mmol/L

4.0 ± 0.1

3.6 ± 0.3

4.2 ± 0.5

4.1 ± 0.2

− 0.2 (− 0.4, − 0.1)

0.011

  1. Values are mean ± SD at baseline and 4-h average for each treatment and between-treatment pairwise comparison (95% CI) and associated P-values from a mixed model, which incorporated repeated measurements. LAC = half-molar sodium lactate; SAL = hypertonic sodium chloride. Bold text highlights P values < 0.05
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Critical Care

ISSN: 1364-8535