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Table 1 Hemodynamic parameters

From: Cardiovascular effects of lactate in healthy adults

 

LAC

SAL

Difference (95% CI)

P value

Baseline

After treatment

Baseline

After treatment

Lactate, mmol/L

0.8 ± 0.3

2.5 ± 0.8

0.9 ± 0.3

0.9 ± 0.3

1.9 (1.8, 2.0)

 < 0.001

Cardiac output, L/min

4.8 ± 0.7

6.5 ± 1.0

5.2 ± 1.4

5.9 ± 1.5

1.0 (0.5, 1.4)

 < 0.001

Stroke volume, mL

82 ± 16

100 ± 18

93 ± 21

98 ± 20

11 (4, 17)

0.002

Heart rate, min−1

59 ± 9

66 ± 7

56 ± 8

61 ± 8

3 (− 1, 6)

0.15

Mean arterial pressure, mmHg

91 ± 8

88 ± 5

86 ± 4

89 ± 8

− 0.3 (− 3.4, 2.8)

0.84

Systolic blood pressure, mmHg

127 ± 9

127 ± 7

122 ± 10

127 ± 12

− 5 (− 9, − 1)

0.023

Diastolic blood pressure, mmHg

72 ± 8

69 ± 6

67 ± 4

70 ± 8

− 4 (− 8, 1)

0.11

sPAP, mmHg

22.7 ± 3.7

19.3 ± 6.0

16.8 ± 7.5

21.1 ± 4.7

− 4.8 (− 9.6, 0.0)

0.049

LVSW/EDV, g/mL

0.64 ± 0.13

0.85 ± 0.29

0.71 ± 0.28

0.73 ± 0.26

0.18 (0.06, 0.31)

0.005

PRSW, g/cm2

84 ± 13

101 ± 20

89 ± 20

96 ± 19

10 (1, 19)

0.031

Ees, mmHg/mL

1.19 ± 0.30

1.32 ± 0.32

1.10 ± 0.23

1.15 ± 0.29

0.07 (− 0.05, 0.19)

0.23

Systemic vascular resistance, WU

18.5 ± 4.4

13.2 ± 2.2

16.5 ± 4.6

15.0 ± 3.9

− 3.3 (− 4.9, − 1.8)

 < 0.001

Ea, mmHg/mL

1.44 ± 0.27

1.18 ± 0.22

1.24 ± 0.33

1.22 ± 0.28

− 0.20 (− 0.29, − 0.12)

 < 0.001

  1. Values are mean ± SD at baseline and 4-h average for each treatment and between-treatment pairwise comparison (95% CI) and associated P-values from a mixed model, which incorporated repeated measurements. Ea = effective arterial elastance; LAC = half-molar sodium lactate; LVSW/EDV = left ventricular stroke work normalized to end-diastolic volume; PRSW = preload-recruitable stroke work; SAL = hypertonic sodium chloride; sPAP = systolic pulmonary arterial pressure; WU = Wood units. Bold text highlights P values < 0.05
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Critical Care

ISSN: 1364-8535