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Fig.6 | Critical Care

Fig.6

From: REmoval of cytokines during CArdiac surgery (RECCAS): a randomised controlled trial

Fig.6

Pre- versus post-adsorber cytokine serum concentrations under HA during surgery and clearance. Boxplots illustrating the levels of cytokines, IL-6 (B), IL-8 (C), IL-10 (D), TNF-alpha (E)), fibrinogen (F), free haemoglobin (G), and myoglobin (H) pre- and post-adsorber (dark grey) haemoadsorption (HA) during cardiothoracic surgery with cardiopulmonary bypass (CPB) at 10, 30, and 60 min compared to baseline (preoperative, white). (I) Clearance of IL-6, IL-8, and IL-10 at 10, 30, and 60 min after CPB initiation. Individual clearance trajectories demonstrate positive clearance values for IL-6 and IL-8 at least at one timepoint. For IL-6, three patients, for IL-8, two patients, initially exhibited negative clearance values. Data is based on n = 19 participants from the treatment group only. All variables are presented as boxplots (10th–90th percentile, median, plus mean values). Statistical analysis for (A–H) Wilcoxon test if normality was not met (Kolmogorov–Smirnov) or paired t-test for fibrinogen and TNF-α. n = 19, *p < 0.05, ** < 0.01, *** < 0.001

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Critical Care

ISSN: 1364-8535