Table 3 Unadjusted, inverse probability treatment weighting (IPTW) adjusted association, and overall interaction between latent profile phenotypes and common sepsis treatments on odds of complicated course in the cohort
From: Identification and transcriptomic assessment of latent profile pediatric septic shock phenotypes
Treatment effect | Phenotype 1 | Phenotype 2 | P interaction | ||
|---|---|---|---|---|---|
OR (95% CI) | p value | OR (95% CI) | p value | ||
> 100 ml/kg fluid | |||||
 Unadjusted | 2.67 (1.47–4.86) | 0.0013 | 1.91 (1.39–2.63) | < 0.0001 |  |
 IPTW Adjusted | 2.93 (1.95–4.38) | < 0.0001 | 1.75 (1.40–2.17) | < 0.0001 | 0.184 |
≥ 2 Antimicrobials | |||||
 Unadjusted | 3.53 (1.34–9.31) | 0.0108 | 0.91 (0.55–1.52) | 0.7294 |  |
 IPTW Adjusted | 3.02 (2.00–4.56) | < 0.0001 | 0.82 (0.66–1.01) | 0.0577 | 0.016 |
≥ 2 Vasoactives | |||||
 Unadjusted | 2.44 (1.35–4.41) | 0.0031 | 1.91 (1.41–2.59) | < 0.0001 |  |
 IPTW Adjusted | 1.63 (1.07–2.48) | 0.0218 | 1.66 (1.34–2.05) | < 0.0001 | 0.624 |
Corticosteroids use | |||||
 Unadjusted | 2.88 (1.55–5.37) | 0.0008 | 1.7 (1.25–2.31) | 0.0007 |  |
 IPTW Adjusted | 2.55 (1.70–3.85) | < 0.0001 | 1.49 (1.20–1.85) | 0.0003 | 0.102 |