Fig. 4
From: Identification and transcriptomic assessment of latent profile pediatric septic shock phenotypes
Inference of cell subsets underlying latent profile phenotypes identified in the study. The figure shows the Uniform Manifold Approximation and Projection (UMAP) of the publicly available single-cell transcriptomic dataset from critically ill adults with sepsis published by Kwok et al. a Ten cell subsets were identified in the single-cell dataset. (1) Developing neutrophils (pink), (2) Mature neutrophils (red), (3) Cluster differentiation (CD) 14 positive monocytes (light gray), (4) CD16 positive monocytes (black), (5) B lymphocytes (deep purple), (6) PB: Plasmablasts (purple), (7) CD4 positive T lymphocytes (moss green), (8) CD8 positive T lymphocytes (yellow), (9) NK: Natural killer cells (blue), and (10) Platelets (brown). b Upregulated genes among patients with Phenotype 1 shown in red, c downregulated genes among patients with Phenotype 1 shown in red, and d composite gene score representing geometric mean of upregulated minus downregulated genes among patients belonging to Phenotype 1. The gene score was scaled as shown in the legend. Cells in red represent those with a high composite gene score indicating that they contributed predominantly to over-expressed genes among patients with Phenotype 1. In contrast, cells in blue represent those with a low composite gene score indicating that they contributed predominantly to genes underexpressed among patients with Phenotype 2