Your privacy, your choice

We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media.

By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection.

See our privacy policy for more information on the use of your personal data.

for further information and to change your choices.
Skip to main content
Fig. 3 | Critical Care

Fig. 3

From: Identification and transcriptomic assessment of latent profile pediatric septic shock phenotypes

Fig. 3

Transcriptomic assessment of latent profile phenotypes of pediatric septic shock. a Volcano plot showing differentially expressed genes among patients belonging to Phenotype 1 relative to those Phenotype 2 using a log2(fold change) threshold of ± 0.25. Overexpressed genes are shown in red. Underexpressed genes are shown in blue. The top 10 most differentially expressed genes are labeled including matrix metallopeptidase-15 (MMP15), chemokine ligand 20 (CCL20), proteinase 3 (PRTN3), neutrophil expressed elastase (ELANE), cathepsin G (CTSG), defensin 3 (DEFA3), defensin 4 (DEFA4), chemokine ligand 4 (CCL4), scratch family transcriptional repressor 2 (SCRT2), and adhesion G protein-coupled receptor E3 (ADGRE3). b Biologically enriched pathways among patients with Phenotype 1 relative to those in Phenotype 2. The y-axis represents the REACTOME pathways enriched for the significantly overexpressed genes. The x-axis represents the gene-ratio (%). The size of the circle indicates gene counts. The darker hue of color indicates a lower adj. p value

Back to article page

Critical Care

ISSN: 1364-8535