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Table 2 Event characteristics

From: Early bolus epinephrine administration during pediatric cardiopulmonary resuscitation for bradycardia with poor perfusion: an ICU-resuscitation study

 

Overall (N = 452)

Epinephrine bolus ≤ 2 min

P-value

Yes
 (N = 322)

No 
(N = 130)

Immediate cause(s) of event

 Respiratory decompensation

266 (59%)

182 (57%)

84 (65%)

0.14

 Hypotension as immediate cause of event

253 (56%)

194 (60%)

59 (45%)

0.01

 Arrhythmia

43 (10%)

30 (9%)

13 (10%)

0.86

 Cyanosis without respiratory decompensation

21 (5%)

11 (3%)

10 (8%)

0.08

Duration of CPR (min)

9.0 [4.0,24.0]

9.0 [4.0,23.0]

7.5 [3.0,26.0]

0.88

Category of Duration of CPR (min)

   

0.74

 < 6

175 (39%)

123 (38%)

52 (40%)

 

 6–15

113 (25%)

82 (26%)

31 (24%)

 

 16–35

77 (17%)

58 (18%)

19 (15%)

 

 > 35

87 (19%)

59 (18%)

28 (22%)

 

CPR timea

   

0.53

 Weekday

235 (52%)

162 (50%)

73 (56%)

 

 Weeknight

83 (18%)

62 (19%)

21 (16%)

 

 Weekend

134 (30%)

97 (30%)

36 (28%)

 

Pharmacologic interventions during event

 Epinephrine

406 (90%)

322 (100%)

84 (65%)

 < 0.001

 Minutes to first doseb

1.0 [0.0.,2.0]

1.0 [0.0,1.0]

3.0 [3.0,6.0]

 

 Number of dosesb

3.0 [1.0,6.0]

3.0 [1.0,6.0]

3.0 [1.0,5.5]

0.80

 Average interval between dosesc

4.1 [3.2,6.0]

4.0 [3.2,5.8]

4.6 [3.1,6.3]

0.42

 Atropine

69 (15%)

49 (15%)

20 (15%)

1.00

 Calcium

198 (44%)

154 (48%)

44 (34%)

0.01

 Sodium bicarbonate

237 (52%)

187 (58%)

50 (39%)

 < 0.001

 Vasopressin

20 (4%)

13 (4%)

7 (5%)

0.61

 Amiodarone

12 (3%)

7 (2%)

5 (4%)

0.34

 Lidocaine

11 (2%)

7 (2%)

4 (3%)

0.52

 Fluid bolus

124 (27%)

96 (30%)

28 (22%)

0.08

  1. aWeekday is between 7 A.M. and 11 P.M. Monday–Friday; weeknight is after 11 P.M. Monday Thursday; weekend is from 11 P.M. on Friday through 7 A.M. on the following Monday
  2. bMinutes to first dose of epinephrine and number of doses of epinephrine is only calculated on subjects who received at least 1 dose of epinephrine
  3. cAverage interval between epinephrine doses is only calculated on subjects with at least 2 doses of epinephrine
  4. CPR, cardiopulmonary resuscitation.