Fig. 4

Dose Response Association of PaO2 value per ICU day with 28-day mortality. Restricted Cubic Spline Models of Hazard Ratios of PaO2 value per ICU day and 28-day Mortality. (A) ICU day 1, (B) ICU day 2, (C) ICU day 3. Knots set at the 5th, 35th, 65th, and 95th percentiles of PaO2. Reference is the 5th percentile. Solid lines, hazard ratios; shadow, 95% confidence interval. Model adjusted for age, sex, comorbidities (Lung, Neurology, Liver, Kidney, and Hematology malignancy), infection site, initial sequential organ failure assessment score, lactate level, treatments (steroid and source control), organ support at ICU Day 1 (mechanical ventilation, continuous renal replacement therapy, and vasopressor)