Table 1 Induction and model development periods
From: A long-lasting porcine model of ARDS caused by pneumonia and ventilator-induced lung injury
Pneumonia with VILI | Pneumonia without VILI | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Injurious ventilation | P. aeruginosa inoculum | Injurious ventilation (inoculum to pneumonia diagnosis) | Injurious ventilation (pneumonia diagnosis to ARDS diagnosis) | ARDS (to the end of the experiment) | Protective ventilation | P. aeruginosa inoculum | Protective ventilation (inoculum to pneumonia diagnosis) | Pneumonia (to the end of the experiment) | ARDS | |
Duration (h) | 3.1 ± 0.1 | 0.9 ± 0.1 | 12.0 ± 0.7 | 16.0 ± 2.3 | 46.8 ± 7.7 | 3.1 ± 0.2 | NA | 7.2 ± 1.1 | 82.4 ± 1.2 | NA |
FiO2 (%) | 100.0 ± 0.0 | 100.0 ± 0.0 | 100.0 ± 0.0 | 100.0 ± 0.0 | 100.0 ± 0.0 | 41.3 ± 0.0 | NA | 40.6 ± 0.6 | 44.4 ± 1.1 | NA |
TV (mL/kg) | 33.3 ± 2.4 | 10.5 ± 0.0 | 27.5 ± 1.6 | 25.1 ± 0.9 | 5.7 ± 0.2 | 8.1 ± 0 | NA | 7.8 ± 0.2 | 7.2 ± 0.1 | NA |
RR (breaths/min) | 12.3 ± 0.0 | 20.0 ± 0.0 | 11.3 ± 0.9 | 10 ± 0.0 | 45.8 ± 1.0 | 15.4 ± 0.4 | NA | 16.8 ± 0.1 | 23.7 ± 1.1 | NA |
PEEP (cmH2O) | 0.0 ± 0.0 | 3.0 ± 0.0 | 4.9 ± 0.0 | 4.9 ± 0.1 | 9.5 ± 0.3 | 4.0 ± 0.0 | NA | 4.3 ± 0.0 | 4.8 ± 0.2 | NA |
DP (mmHg) | 27.7 ± 0.2 | 12.5 ± 0.0 | 30.1 ± 0.3 | 29.9 ± 0.2 | 17.7 ± 0.5 | 9.5 ± 0.5 | NA | 12.3 ± 0.0 | 13.5 ± 0.4 | NA |
MP | NA | 10.5 ± 1.6 | 34.7 ± 0.8 | 28.35 ± 1.2 | 26.9 ± 1.7 | 5.23 ± 0.7 | NA | 6.65 ± 1.0 | 10.1 ± 0.3 | NA |
Ventilatory mode | PC | VC | PC | PC | VC | VC | NA | VC | VC | NA |