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Table 1 Baseline characteristics of patients before and after propensity matching

From: Inhaled nitric oxide and the risk of renal dysfunction in patients with acute respiratory distress syndrome: a propensity-matched cohort study

Characteristic

Overall cohort (n = 547)

Propensity-matched cohort (n = 302)

iNO users (n = 216)

Non-users (n = 331)

P value

iNO users (n = 151)

Non-users (n = 151)

P value

Age, years

61 ± 17

64 ± 16

0.07

63 ± 17

62 ± 16

0.59

Female sex, n (%)

66 (30.6)

114 (34.4)

0.34

48 (31.8)

50 (33.1)

0.81

ARDS severity

 Moderate, n (%)

105 (49)

208 (63)

0.001

82 (54)

74 (49)

0.36

 Severe, n (%)

111 (51)

123 (37)

 

69 (46)

77 (51)

 

Body-mass index, kg/m2

23.3 ± 4.7

21.9 ± 3.9

<0.001

22.7 ± 4.7

22.7 ± 4.0

0.95

Cause of ARDS, n (%)

 Pneumonia

167 (77.3)

258 (78.0)

0.52

121 (80.1)

122 (80.8)

0.93

 Non-pulmonary sepsis

32 (14.8)

47 (14.2)

20 (13.3)

19 (12.6)

 Acute interstitial pneumonia

11 (5.1)

10 (3.0)

7 (4.6)

5 (3.3)

 Multiple transfusion

1 (0.5)

5 (1.5)

1 (0.7)

2 (1.3)

 Others

5 (2.3)

11 (3.3)

2 (1.3)

3 (2.0)

Renal function

 Creatinine, mg/dL

1.1 (0.8–1.6)

1.1 (0.8 − 1.8)

0.75

1.1 (0.8 − 1.6)

1.0 (0.8 − 1.7)

0.83

 Creatinine clearance, mL/min

57.0 (35.5 − 82.2)

48.3 (31.0 − 70.2)

0.01

55.2 (35 − 81)

53.8 (33.3–81.5)

0.97

 AKI stage 1, n (%)

57 (78)

91 (79)

 

39 (81)

42 (84)

 

 AKI stage 2, n (%)

9 (12)

13 (11)

0.98

5 (10)

4 (8)

0.91

 AKI stage 3, n (%)

7 (10)

11 (10)

 

4 (8)

4 (8)

 

Shock, n (%)

91 (42.1)

117 (35.4)

0.11

56 (37.1)

56 (37.1)

1.00

SAPS II

49.9 ± 15.1

49.8 ± 14.7

0.95

49.9 ± 14.2

50.2 ± 15.2

0.89

Lung injury score, total score

11.4 ± 1.9

10.95 ± 1.9

0.005

11.3 ± 1.8

11.5 ± 1.8

0.46

FiO2

0.9 (0.6–0.9)

0.7 (0.6–1.0)

<0.001

0.8 (0.6–1.0)

0.8 (0.6–1.0)

0.96

PaO2/FiO2

96 (68 − 134)

123 (84–181)

<0.001

104 (74–143)

99 (66 − 140)

0.45

PEEP, cm H2O

8.9 ± 3.6

8.1 ± 3.0

0.002

8.3 ± 3.4

8.7 ± 3.2

0.35

Tidal volume, mL/pBW

8.7 ± 1.9

8.5 ± 2.0

0.23

8.7 ± 1.9

8.6 ± 2.0

0.82

pH

7.38 ± 0.10

7.39 ± 0.09

0.35

7.39 ± 0.10

7.40 ± 0.08

0.66

PaO2, mmHg

82.0 ± 33.2

94.2 ± 43.4

<0.001

83.9 ± 35.0

80.9 ± 32.0

0.45

PaCO2,mmHg

37.5 ± 10.4

37.1 ± 10.5

0.67

37.4 ± 9.9

37.3 ± 8.7

0.97

HCO3 -, mmol/L

22.0 ± 5.1

22.5 ± 5.6

0.27

22.3 ± 5.2

22.5 ± 4.7

0.66

Static respiratory compliance, mL/cm-H2O

29.6 ± 12.8

29.7 ± 13.1

0.92

29.0 ± 12.4

30.2 ± 13.7

0.45

Plateau pressure, cm H2O

28 ± 6.8

26 ± 7.3

0.03

27 ± 6.1

27 ± 7.9

0.70

Driving pressure (cm H2O)

18.8 ± 6.4

18.2 ± 6.6

0.35

18.5 ± 5.6

18.5 ± 7.1

0.95

Mean airway pressure, cm H2O

15.7 ± 4.3

14.5 ± 3.9

0.002

15.0 ± 4.1

15.2 ± 3.8

0.62

Duration of mechanical ventilation, days

11 (6–20)

12 (7–24)

0.09

12 (6–22)

12 (6–21)

0.93

  1. Data are expressed as the mean ± standard deviation or median (interquartile range) unless otherwise specified. Detailed variables used in the propensity score model are listed in Additional file 1: Table S1. Abbreviations: ARDS acute respiratory distress syndrome, AKI acute kidney injury, iNO inhaled nitric oxide, PEEP positive end-expiratory pressure, pBW predicted body weight, SAPS Simplified Acute Physiology Score
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Critical Care

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