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Table 3 Overview of the GRADE system for grading the quality of evidence: definitions in grading the quality of evidence

From: Evidence-based medicine: Classifying the evidence from clinical trials – the need to consider other dimensions

Level of evidence

Definition

High

Further research is not likely to change our confidence in the effect estimate

Moderate

Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate

Low

Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate

Very Low

Any estimate of effect is uncertain

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Critical Care

ISSN: 1364-8535